天然大腦抗衰劑——迷疊香和留蘭香的天然提取物

天然大腦抗衰劑——迷疊香和留蘭香的天然提取物

【文獻解讀】

2016年10月，美國聖路易斯大學和肯塔基大學的研究團隊在期刊《Physiology & Behavior》上發表了關于鼠尾草酸和迷疊香酸植物提取物對SAMP8小鼠學習記憶的影響的文章。結果表明，從迷疊香和留蘭香中提取的天然産物鼠尾草酸和迷疊香酸，有助于預防衰老小鼠模型相關的學習和記憶障礙。

本試驗以9月齡的小鼠為模式生物，每天分别服用迷疊香提取物（鼠尾草酸）和留蘭香提取物（迷疊香酸）。90天後，作為實驗測試。服用迷疊香提取物的小鼠，改善小鼠在T迷宮足部電擊、物體識别和杠杆按壓中的擷取和保持能力。留蘭香提取物改善了T-迷宮中的擷取和保持能力，避免了腳部電擊和物體識别。結果表明，留蘭香和迷疊香提取物對小鼠的學習記憶和腦組織氧化标記物有有益的影響。

注：含60%鼠尾草酸的迷疊香提取物對T-maze足部避震的影響

本試驗在由于加速衰老而導緻認知衰退的小鼠模型中發現，迷疊香提取物或留蘭香提取物給藥後，小鼠顯示出預防認知衰退的作用。這些結果表明，迷疊香提取物和留蘭提取物是治療年齡相關性認知減退的潛在自然營養幹預措施。

【文獻節選】

current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. The two rosemary extracts contained carnosic acid (60% or 10% carnosic acid) and one spearmint extract contained 5% rosmarinic acid. Three doses of actives in each extract were tested: 32, 16, 1.6 or 0 mg/kg. After 90 days of treatment mice were tested in T-maze foot shock avoidance, object recognition and lever press. Rosemary extract containing 60% carnosic acid improved acquisition and retention in T-maze foot shock, object recognition and lever press. Rosemary extract with 10% carnosic acid improved retention in T-maze foot shock avoidance and lever press. Spearmint with 5% rosmarinic acid improved acquisition and retention in T-maze foot shock avoidance and object recognition. 4-hydroxynonenal (HNE) was reduced in the brain cortex after treatment with all three extracts (P b 0.001) compared to the vehicle treated SAMP8. Protein carbonyls were reduced in the hippocampus after administration of rosemary with 10% carnosic acid (P b 0.05) and spearmint containing 5% rosmarinic acid (Pb 0.001). The current results indicate that the extracts from spearmint and rosemary have beneficial effects on learning and memory and brain tissue markers of oxidation that occur with age in SAMP8 mice.