INTRODUCTION TO BIOINFORMATICS

   這套教程源自Youtube,算得上比較完整的生物資訊學領域的視訊教程,授課内容完整清晰,專題化的講座形式,細節講解比國内的京師大學堂的Mooc教程好過10000倍.下面是視訊的快速連結還有文檔講義哦,很好的東東,連結分享給國内的朋友們.

=課程首頁:http://ocw.metu.edu.tr/course/view.php?id=37,

   Instructor: Tolga CAN

   Added: 18 November 2009

Topic outline

• General

  • Course OverviewPage
  • National Center for Biotechnology Information, USA.URL
  • Protein Data BankURL

• Topic 1

  Introduction to Bioinformatics
  • Lecture SlidesFile
  • Week 1 - Lecture 1 [Video]File

• Topic 2

  Introduction to biology, biological databases, and high-throughput data sources. Overview of bioinformatics problems.

  Pairwise sequence alignment algorithms: Dynamic programming

  • Assignment 1File
  • Reading: Bioinformatics - An Introduction for Computer ScientistsFile
  • Reading: Cells and GenomesFile
  • Reading: How Cells Read the Genome: From DNA to ProteinFile
  • Reading: The Nucleic Acid WorldFile
  • Reading: Producing And Analzying Sequence AlignmentsFile
  • Week 2 - Lecture 1 [Video]File
  • Week 2 - Lecture 2 [Video]File
  • Week 3 - Lecture 1 [Video]File
  • Week 3 - Lecture 2 [Video]File
  • Week 4 - Lecture 1 [Video]File
  • Week 4 - Lecture 2 [Video]File

• Topic 3

  Statistical significance of alignments - Part I

  Statistical significance of alignments - Part II

  • Reading: Pairwise Sequence AlignmentFile
  • Week 5 - Lecture 1 [Video]File
  • Week 5 - Lecture 2 [Video]File
  • Week 5 - Lecture 3 [Video]File

• Topic 4

  Suffix Trees, Suffix Arrays
  • Week 6 - Lecture 1 [Video]File
  • Week 6 - Lecture 2 [Video]File

• Topic 5

  Patterns, Profiles, and Multiple Alignments
  • Assignment 2File
  • Week 6 - Lecture 3 [Video]File

• Topic 6

  Hidden Markov Models

  Week 5 Lecture Slides Continued

  • Week 7 - Lecture 1 [Video]File
  • Week 7 - Lecture 2 [Video]File
  • Week 7 - Lecture 3 [Video]File

• Topic 7

  Multiple Sequence Alignment Algorithms
  • Week 8 - Lecture 1 [Video]File
  • Week 8 - Lecture 2 [Video]File
  • Week 8 - Lecture 3 [Video]File

• Topic 8

  Midterm Review and Midterm Exam
  • Midterm ExamFile
  • Midterm KeyFile
  • Phylogenetic trees

• Topic 9

  Introduction to protein structures

  Structure Prediction

  • Assignment 3 for Computer Engineering MajorsFile
  • Assignment 3 for Biology or Genetics MajorsFile
  •  Week 9 - Lecture 1 [Video]File
  •  Week 9 - Lecture 2 [Video]File
  •  Week 9 - Lecture 3 [Video]File
  •  Week 9 - Lecture 4 [Video]File

• Topic 10

  Protein Structure Prediction (continued)
  •  Week 10 - Lecture 1 [Video]File
  •  Week 10 - Lecture 2 [Video]File
  •  Week 10 - Lecture 3 [Video]File

• Topic 11

  • Week 11 - Lecture 1 [Video]File
  • Week 11 - Lecture 2 [Video]File
  • Week 11 - Lecture 3 [Video]File

• Topic 12

  Structural Alignment of Proteins

  (lecture notes continued)

  • Week 12 - Lecture 1 [Video]File
  • Week 12 - Lecture 2 [Video]File
  • Week 12 - Lecture 3 [Video]File

• Topic 13

  Microarray data normalization, analysis

  Clustering techniques

  • K-means DemoFile
  • Self Organizing Maps DemoFile
  • Reading: Microarrays Intro Paper - 1File
  • Reading: Microarrays Intro Paper - 2File
  • Reading: Microarrays Intro Paper - 3File
  • Week 13 - Lecture 1 [Video]File
  • Week 13 - Lecture 2 [Video]File

• Topic 14

  Introduction to Systems Biology

  Gene regulatory networks

  • Assignment 4File
  • Dataset for Assignment 4File
  • Week 14 - Lecture 1 [Video]File

• Topic 15

  Construction and Analysis of protein networks:

  Monte Carlo Sampling, Random Walks on Graphs

  • Likelihood Computation ExampleFile
  • Week 15 - Lecture 1 [Video]File
  • Week 15 - Lecture 2 [Video]File
  • Final review