#健康科普大赛 #
On the way to work, a grandfather covered his face and came in, telling about facial jaw pain, sometimes light and sometimes painful, began to think that toothache, he ate painkillers, the effect was not obvious, especially not hardy, brushing teeth with cold water, the pain was aggravated, like a knife scraping. According to his symptoms, there was redness in the face, one side was in severe pain, suspected to be trigeminal neuralgia, recommended him to use carbamazepine, the old man was also very cooperative, took the medicine and went home. It was almost time to leave work, the son of the old man came over, came in with a temper, asked why he let his father take drugs for epilepsy, and inquired on the Internet, carbamazepine is used to treat epilepsy. After calming his mood, he slowly gave him the original explanation before he left with confidence. In fact, many drugs have different indications, which can be selected according to the needs of the condition.
function:
Carbamazepine, as the first choice for epilepsy diseases; it is also the first choice for trigeminal neuralgia; it can also be used for mania, neuropathic pain caused by diabetes, primary diabetes insipidus, glossopharyngeal neuralgia, and can also be used to prevent and treat depression!
Principle of action :
Carbamazepine belongs to the dibenzozozophrene epileptic drugs, the main principle is to enhance the inactivation of sodium channels, limit the divergence of high-frequency action potentials of postsynaptic neurons, and block the release of neurotransmitters by blocking presynaptic sodium channels and action potential divergence, thereby regulating nerve excitability and producing antiepileptic effects. Used for trigeminal neuralgia is also to block neurons, producing an analgesic effect.
Use Caution:
(1) For trigeminal neuralgia, it can not be used with acetaminophen, which can increase hepatotoxicity and also reduce the effect of acetaminophen.
(2) Because carbamazepine is an inducer of liver drug enzymes, and some anticoagulants, such as coumarin anticoagulant warfarin, can reduce the blood concentration of anticoagulants, weaken the anticoagulant effect, and need to adjust the dose of anticoagulants.
(3) For depression; combined with antidepressant monoamine oxidase inhibitors (moclobemide), it can produce hyperthermia and hypertensive crisis, which can cause death in severe cases, and the use of the two drugs needs to be at least 14 days apart.
(4) For epilepsy, with oxcarbazepine, phenytoin sodium use, cross-drug resistance will occur.
(5) Heart, kidney and liver insufficiency, the first trimester of pregnancy, lactation is contraindicated. Diabetes, glaucoma, cardiovascular and cerebrovascular diseases should be used with caution. Regular poor liver function, urinary routine, fundus examination during taking the drug.
(6) Epilepsy treatment, sudden cessation will cause seizures! The medication should also be started in small doses, and the discontinuation of the drug should also be stopped in small doses.
Adverse reactions :
1. Drowsiness, dizziness, rash, dry mouth, nausea and vomiting, leukopenia
2. It can cause blurred vision, convulsive coma, and ataxia
3. Rare aplastic anemia, liver damage, urinary retention
In short, whether it is epilepsy or trigeminal neuralgia, in the early stage, it is still necessary to go to the hospital, confirm the disease and then use it under the guidance of a doctor and pharmacist!