IT House reported on January 9 that Park Joon-kyu, south Korean CEO of Riot Games, a developer of League of Legends, died of liver cancer in Seoul on January 9 at the age of 44.
Fist South Korea issued an obituary saying that Park Joon-kyu was diagnosed with liver cancer last year, and has been actively treated and insisted on working since then, until the end of last year, when he was still in charge of the company's business, and other matters related to his position have not yet been decided.
Liver cancer is one of the most common cancers in the world, and China is a "big country with liver cancer". According to statistics, more than 50% of the world's new and dead liver cancer cases occur in China.
Many people in life like to drink, and sometimes for work, or to attend some party, alcohol is also essential. However, some people drink regularly, and if they find that their alcohol consumption has suddenly dropped, or compared to usual, and they are somewhat unwell, then they should start paying attention, because this is likely to promote liver damage.
< h1 class="pgc-h-arrow-right" > liver cancer is associated with excessive alcohol consumption? </h1>
According to statistics, more than half of liver cancer patients are related to alcohol consumption. Drinking three glasses of beer a day may be a risk factor for the development of liver cancer. For every ten grams of alcohol consumed per day, the risk of liver cancer increases accordingly. Cases of advanced liver cancer like Lao Liu are not uncommon in hospitals. With the improvement of living conditions, heavy alcohol consumption and a variety of high-fat and high-fat diets are one of the important reasons for long-term damage to the liver. When many people are diagnosed with liver cancer, most of them are actually in advanced stages.
< h1 class= "pgc-h-arrow-right" > so what changes in the body indicate that liver cancer is coming? </h1>
First, there is pain on the upper right side of the abdomen
People who drink alcohol regularly, when they find pain on the upper right side of the abdomen, is a manifestation of liver damage, and may also be pain in the liver area caused by the spread of liver tumor cells, which is also one of the most common symptoms of liver cancer.
Second, indigestion occurs
The manifestations of indigestion are such as bloating, generally after meals there is a feeling of bloating, there may also be postprandial nausea and vomiting and other manifestations, while most people can not eat some greasy food, loss of appetite and so on.
Third, changes in the skin
About 25% of patients with abnormal liver function may have dull skin and often feel itchy skin for no reason, and there is also the appearance of a spider mole, that is, there is a red dot in the middle, surrounded by blood streaks of spider webs.
Fourth, fatigue and weakness
If the liver function is abnormal, or the liver is too heavy, it will lead to general weakness, mental atrophy, and often feel that nothing can be done to lift the spirit.
Fifth, weight loss
Predominantly manifests as weight loss in patients, or in the absence of a significant cause of weight loss. Whether it is liver cancer or not, sudden weight loss is an abnormal phenomenon that must be paid attention to.
Preventing liver cancer is a long battle!
The survival rate of liver cancer is very low, so we should take effective measures to reduce the chance of its occurrence.
Abstinence in alcohol: It is best to quit alcohol, after all, this is a first-class carcinogen. If you can't quit, you should also moderate it.
Tobacco restriction: the same first-degree carcinogens, the same advice is best to quit. The same is impossible to quit, but also to control.
Hepatitis B vaccination: reduces cirrhosis and liver cancer caused by hepatitis B. Especially people who share needles with drug users or have sex without protection with people who are at risk of hepatitis B.
Weight control: Obesity can lead to fatty liver and diabetes, increasing the risk of liver cancer, so keep your weight at a reasonable level.
Active treatment of related diseases: The above-mentioned diseases such as hepatitis B, hemochromatosis, and diabetes should be actively treated before they become liver cancer to reduce the risk.
<h1 class="pgc-h-arrow-right" > have liver cancer, how to treat it? </h1>
1. Surgical treatment
General condition of patients: good general condition, no serious damage to heart, lung and kidney function, it is estimated that surgery can be tolerated; liver function is well compensated, or only mild damage, according to liver function classification of grade 1, or grade 2, after short-term liver protection treatment, liver function returned to grade 1; no extensive liver metastatic tumors.
2. Chemotherapy
Depending on the patient's specific situation, selective regional chemotherapy, such as transhepatic artery and esophageal varices, the tumor is limited, there is no distant metastasis, and it is not suitable for surgical resection or recurrence after surgery, and it is recommended to use radiotherapy-based comprehensive treatment.
3. Radiotherapy
Radiotherapy is good for general conditions, liver function is still good, not accompanied by cirrhosis, no jaundice, ascites, no hyperplenic function and esophageal varices, tumor is more limited, there is no distant metastasis, and is not suitable for surgical resection or recurrence after surgery, chemotherapy can be used.
<h2 class="pgc-h-arrow-right" > the next outlet for liver cancer treatment has arrived! </h2>
Immunotherapy in combination with other standard cancer treatment modalities
Immune cell therapy has been the theme of our times, immune-based combination therapy, including immune combined chemotherapy, immune combined TACE, immune combined radiotherapy, immune combined immunity, immune combined anti-neovascular drugs, is the direction of our future exploration, in the present and future for liver cancer patients to solve cancer problems, alleviate pain, prolong the life cycle, improve the quality of life.
< H1 class= "pgc-h-arrow-right" > the results of immunotherapy for liver cancer continue to occur</h1>
On 3 March, PD-1 monoclonal antibody- carellizumab (Erica ®) was officially approved by the State Drug Administration for the treatment of patients with advanced hepatocellular carcinoma who had received sorafenib treatment and/or chemotherapy containing oxaliplatin system.
On March 11, the FDA approved Opdivo (1 mg/kg) + Yervoy (3 mg/kg) for the treatment of patients with hepatocellular carcinoma (HCC) who had previously been treated with sorafenib, the fourth indication for O+Y harvesting.
HCC's powerful immune-mediated pathogenesis makes this tumor particularly suitable for immune-based therapy. However, the complex functional characteristics of the HCC tumor microenvironment (TME) highlight the high resistance barrier to immunotherapy.
Systematic treatment of patients with HCC has traditionally been challenged by endogenous chemical resistance and concomitant liver dysfunction. For patients who are not candidates for liver transplantation, resection, or topical therapy, the mainstay of treatment is multi-target molecular therapy with sorafenib or lomvatinib. While these therapies are effective in improving survival, they largely inhibit cell growth, and drug resistance is an important limiting factor in long-term survival.
With the continuous exploration and advance of the combination of immunotherapy, there will be more choices for the treatment of liver cancer patients in the future, and it is expected to further improve the quality of life of patients and improve patient survival.
For more treatment questions, please feel free to leave a comment or send a private message to me.#Liver Cancer##癌症 #