#Vitiligo ## Health Decryption ## Popular Science # Many people say that the diagnosis of vitiligo is relatively easy, and there are many ways to detect themselves on the Internet, but the symptoms of vitiligo have similar conditions to other diseases. Many vitiligo patients blindly carry out treatment according to some unscientific examinations, resulting in more and more serious diseases. Before treating vitiligo, it is necessary to do some accurate and professional examinations, let's take a closer look at the examination methods involved.
Let's learn together
First, blood tests
It is necessary for the patient to do some blood tests before or during treatment, from which we can detect abnormalities or potential visceral lesions. Identifying the cause can improve the cure rate of vitiligo and help with recovery. Blood tests are the most basic tests for vitiligo patients;
Second, wood lamp check
WOOD lamp is a standard instrument for identifying vitiligo, which uses the principle of melanin to absorb full-wave ultraviolet rays, obtain 320-400nm long-wave ultraviolet rays through a filter, and then irradiaze the affected area with long-wave ultraviolet rays. If melanin decreases, the refractive light is strong and milky white, while the increase in melanin is weak and dark. It can accurately detect how much melanin is lost and distinguish between complete or incomplete vitiligo. Sometimes it is clinically difficult for the naked eye to find normal skin, especially light spots on fair skin or some occult white spots. The skin of the affected area under the WOOD lamp contrasts sharply with the surrounding normal skin, the boundaries are clear, while the changes in dermal pigment are not obvious;
Third, three-dimensional skin CT examination
It uses the principle of optical focusing and uses computerized three-dimensional tomography technology to enable us to more intuitively, real-time and dynamically observe the occurrence, development and lesion changes of vitiligo in patients. It can accurately locate the patient's leukoplakia, quickly scan whether their subcutaneous melanocytes are alive and survive, and can provide a more scientific and reliable basis for the treatment of various types of refractory vitiligo, especially the long-term incurable vitiligo. Compared with traditional pathological biopsy, it has the advantages of non-invasive and painless, high patient comfort, and rapid examination;
Fourth, the homomorphic reaction examination method
First the tool is routinely disinfected with alcohol, and then at the normal skin of the patient's shoulder deltoid muscle area, a tic-tac-toe mark is drawn with a disinfection pox needle, and the scratch is checked after 1 month, if the pigmentation is positive, it is vitiligo, and no pigment change is negative, it is not vitiligo;
Fifth, tyrosinase detection
Tyrosinase is crucially related to the formation of vitiligo. We all know that the most direct cause of vitiligo is the loss of melanin, and tyrosinase is an important oxidase in the chemical reaction of synthetic melanin. By detecting tyrosinase activity, the true cause of the disease in vitiligo patients can be accurately detected;
Sixth, trace element detection
According to studies, the incidence of vitiligo is closely related to trace elements such as copper, zinc, iron and selenium. Most clinical vitiligo patients have copper ions or ceruloplasmin levels in their blood and skin below healthy standards. Moreover, studies have confirmed that tyrosinase is based on copper ions as auxiliary groups, and its activity is closely related to copper ions. Trace element detection is essential when examining vitiligo;
Seventh, anti-melanocyte antibody detection
The anti-melanocyte IgG antibody in the patient's blood was detected and its relationship with disease activity and pathogenesis type was analyzed. We found that the level of antimelanocyte antibodies in patients with advanced vitiligo was significantly higher than in stable and normal patients, and the level of generalized patients with advanced vitiligo vulgaris was significantly higher than that in localized patients. Anti-melanocyte IgG antibodies in the blood of vitiligo patients have a certain relationship with disease activity and pathogenesis, supporting vitiligo and autoimmunity. Anti-melanocyte antibodies in the serum will damage the normal function of melanocytes, damaged melanocytes can release antigens, stimulate the body to produce more antimelanocyte antibodies, so the vicious cycle continues, resulting in more and more damaged melanocytes;
Eighth, microcirculation disorder detection
Through fluorescence microscopy, the microcirculation on the periphery of the body is examined, including examination of the parts of the body that often have white spots, such as the nail folds, bulbous conjunctiva, the tip of the tongue, the lips, the gums, etc., and the common is the microcirculation of the fingernail fold and the microcirculation of the ball conjunctiva. It can not only detect the cause of the patient's disease, but also check whether the patient has some other diseases, providing a basis for the accurate diagnosis and treatment plan of vitiligo patients.
When treating vitiligo, it is particularly important to detect the specific cause. Only by detecting the specific cause can we prescribe the right medicine and precise treatment to shorten the cycle of vitiligo treatment. Friends of vitiligo patients must go to a regular hospital for examination. Early detection, early treatment, early recovery.
I am your Dr. Li Qiong, and any doubts about vitiligo can always give me a private message and a message. Treat vitiligo, I'm with you all the way!