Tension and Skin Defect Model Mouse Skin Regeneration summary of 3D printed controllable tension bands:

<h1 class="pgc-h-arrow-right" data-track="1" > Abstract:</h1>

Title Interpretation:

Skin defects: for the loss of skin tissue caused by trauma, burns, tumors and other reasons, the current commonly used clinical treatment methods include skin grafting, flap grafting, etc.

Lace-binding technology: it is a treatment method for skin defect wounds, similar to shoelaces, sutures or silicone threads cross each other back and forth from both sides of the wound, which can evenly disperse the tension of the sutures to the edge of the skin defect wound, effectively stimulate the proliferation of the skin edges, thereby treating skin defects.

Background: Although the tension band technology can stimulate skin regeneration to repair skin defects, and has been successfully applied to the clinic to achieve satisfactory results, the most suitable tension for skin regeneration is still inconclusive.

ObjectiveTo investigate the effects of different tension stimulation on skin regeneration in rats with skin defects.

Methods: Male 3-month-old SD rats were selected as experimental animals, the back skin of SD rats was fixed by 3D printed oval skin fixation device, the wound model of the back skin defect of rats was established, the 3D printing tension belt device was fixed at the edge of the skin, the silicone loop was installed on the principle of tying shoelaces, and the different tension parameters of the silicone loops (0, 0.2, 1 N) were adjusted by the tension detector .0,0.2,1 N. The changes in the area of skin defects were measured on the same day, 3 days and 7 days after molding, and the skin histology sections of the wound margin were taken 7 days after the molding operation for CD31 and vascular endothelial growth factor immunohistochemical staining to observe the effects of different tension stimulation on skin regeneration.

Results and conclusions: (1) appropriate size of tension stimulation can effectively stimulate skin proliferation and healing; skin defect wound without tension stimulation will further expand with contracture of the skin edge, increasing the area of skin defect, which is not conducive to the treatment of skin defects; (2) tension stimulation is not as big as possible, at the same time point 0.2 N tension group wound shrinks faster than in the 1 N tension group, 1 N tension group can see skin hardening and decreased elasticity at the edge of the wound, considering that it may be caused by skin ischemia due to large tension; (3) 0.2 The number of microvascular in the N-tension group increased significantly, and the expression of vascular endothelial growth factor was significantly higher than that in the 0 N-tension group and the 1 N-tension group, indicating that tension stimulation can promote microvascular formation and improve the expression of vascular endothelial growth factor, but high-tension stimulation (1 N in this study) is not conducive to the formation of microvascular microvascular around skin defects and is not conducive to wound healing; (4) suggests that appropriate tension stimulation can cause the reconstruction of extensive extracellular matrix in the local skin; it can induce vascular regeneration, Improve the supply of nutrients required for local cellular metabolism and promote the recombination of the cytoskeleton, a process that has strict requirements for the size of the tension.

https://orcid.org/0000-0001-9853-1923 (Maihemuti Yakuf)

The Chinese Journal of Tissue Engineering Research focuses on: artificial joints; bone implants; spine; fractures; internal fixation; digital orthopedics; tissue engineering

Keywords: 3D printing, controllable tension band, skin defect, skin regeneration

Citations: Maihemuti Yakufu, Sun Qinqin, Chen Hongtao, Liu Xu, Illyal Abdusmu, Abdusaramu Abdulklimu, Liu Jianjiang. Tension of Controlled Tension Bands in 3D Printing and Skin Regeneration in Mouse Skin Defect Model[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(3): 387-391.

To read more, please visit the official website of China Tissue Engineering Research Journal

3D printed controllable tension band tension and skin regeneration in a model of skin defects in mouse rats