Effect of oxycodone on analgesic effects after transurethral prostate electroresection and peripheral blood P substance and serotonin concentration
Li Dexiao, Li Bo, Zhuo Deping, Yang Zuxing
Author Affilications: 445800 Department of Anesthesiology, Hefeng County Central Hospital, Hubei Province
【Abstract】 Objective To investigate the effect of oxycodone on the analgesic effect of transurethral prostate electroresection (TURP) and the concentration of peripheral blood P substance and serotonin (5-HT). Methods From September 2019 to August 2020, 99 patients under turp in Hefeng County Central Hospital were selected, and all patients were divided into oxyko group, sufen group and morphine group according to random grouping method, with 33 cases each. The oxycodone group performed oxycodone drug analgesia, the sufen group performed sufentanil analgesia, and the morphine group performed hydromorphone drug analgesia. Comparing the 6, 12, 24, and 48 h visual simulation scoring (VAS) scores of 3 groups after surgery, and the peripheral blood P substance and 5-HT before and after analgesia, 12, 24, and 48 h, the occurrence of adverse reactions in 3 groups was observed. Results The vas scores of 6, 12, 24 and 48 h after surgery were compared in three groups, and the difference was not statistically significant (P>0.05). There was no statistically significant difference in peripheral blood P substances in the first three groups of analgesia (see table P>0.05); compared with peripheral blood P substances in the 12, 24, and 48 h postoperative groups of 3 groups ( P<0.05). Peripheral blood P substance in the 12, 24, and 48 h postoperative oxycos was lower than that in the sulfine group and morphine group (P<0.05). There was no statistically significant difference between 5-HT levels in the first three groups of analgesia (P>0.05); compared with postoperative 12, 24, and 48 h 5-HT levels in the three groups (P<0.05). The 5-HT levels in the 12, 24, and 48 h postoperative oxycos were lower than those in the sulfine group and morphine group (P<0.05). The incidence of adverse reactions in the Oxycoa group was lower than in the morphine group and the sulfine group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions in the morphine group and the sulfine group (P>0.05). Conclusions Oxycodone, sufentanil and hydromorphone have good analgesic effect after TURP surgery, but oxycodone has a strong inhibitory effect on peripheral blood P substance and 5-HT concentration, and the safety is higher.
【Keywords】 Oxycodone; sufentanil; hydromorphone; transurethral prostate electroresection; analgesic effect; peripheral blood P substance; serotonin 5
【 DOI】 10.15887/j.cnki.13-1389/r.2021.24.013
