Mosinock differs from other multi-component macrolide antiparasitic drugs (e.g., ivermectin, avermectin, mebemycin) in that it is a single component and maintains anti-insect activity for a longer period of time. Mosinock has broad-spectrum deworming activity and is highly repulsive to nematodes and arthropod parasites in dogs, cattle, sheep and horses.
As a new generation of deworming antibiotics, mosinok has a higher concentration of drugs in tissues and other body fluids, the average residence time in the body is higher than in the blood plasma, and the corresponding value of ivermectin is relatively high. Mosinock can exert its effect in the body for a long time.
In addition, due to the large range of safe doses of the drug to ivermectin-sensitive animals. It can relatively reduce the incidence of drug poisoning. Moreover, Mosinok is not only highly effective against in vivo and in vitro parasites, but also inhibits the development of eggs in some insect bodies.
The toxicity of mosinoc and ivermectin is basically similar, showing salivation, gait waddling, generalized tremor spasms, and severe coma. Toxicity generally does not occur within the normal dose range, because the peripheral nerve conduction medium in mammals is acetylcholine; the nerves with GABA as the conduction medium are only present in the central nervous system, but mammals have a blood-brain barrier, so the drug enters the central nervous system very little. So far, no glutamate-containing gated CL channel has been found in mammals, so it has a high safety profile for mammals, and mosinogram has a greater safety range than ivermectin.
Therefore, the insect repellent for pigs can be used to use mosinoke, which is safe for pregnant animals and milk production.
At lower doses (0.5 mg/kg or less), mosinock is highly repulsive to endopses (nematodes) and exoplasms (arthropods). This product is mainly used in most gastrointestinal nematodes and lung nematodes in ruminants and horses, some arthropod parasites in ruminants, and developing larvae of canine filaria.
Cattle cattle mainly use Mosinoque injections and pouring agents, more than 99% of the highly efficient insect bodies are: Oster nematode adults and larvae, bovine back-mouth nematode adults and stage 4 larvae, lyre-shaped Osteriasis, Boeth's blood spear nematode, Ai's hairy worm, snake-shaped hairy worm, colorless hairy nematode, radiation esophageal nematode and fetal reticulosis.
