From 2009 to 2014, a statistical analysis of the drug use of 595 patients with drug-induced liver damage caused by traditional Chinese medicine in the 302nd Hospital of the People's Liberation Army found that 40 cases of drug-induced liver damage caused by traditional Chinese medicine formulas containing bone fat were found;
From January 2004 to July 2016, a total of 2 665 adverse reaction reports and 81 cases of severe liver damage were reported in the National Adverse Drug Reaction Monitoring Database, and the oral preparation of Xianling Bone Bao contained psoralen.
In 2016, the National Adverse Drug Reaction Monitoring Center reported vigilance against the risk of liver injury caused by xianling bone-tonic oral preparations (including psoralen);
In 2017, the State Food and Drug Administration revised the instructions for the oral preparation of Xianling Bone Bao (adverse reactions, contraindications and precautions), adding "those with a history of liver disease or abnormal liver biochemical indicators are prohibited".
Bone Kang capsules for psoralin containing psoralin Chinese proprietary medicine preparations, literature reports and adverse reaction monitoring data show that bone Kang capsules have a certain risk of liver injury, in 2018 the State Drug Administration on the revision of the instructions for bone Kang capsules, increase the risk of liver injury prompt information, the adverse reaction items from "not yet clear" revised to "headache, nausea, vomiting, gastrointestinal discomfort, rash, liver function abnormalities, etc.", the contraindications were modified to "liver function abnormalities are prohibited", and prompted under "precautions" Liver and kidney function should be monitored regularly during the administration of the drug."
This is when I found reports of adverse reactions related to Chinese herbal psoralin
Friends who have a little understanding of traditional Chinese medicine will suspect when they see these: psoralen is non-toxic, you are not professional, you must be wrong!
The truth is: Psoralen is a potentially toxic chinese medicine:
Psoralen is a common clinical drug for warm kidneys and yang, and the toxicity of psoralen has been recorded as early as the "Lei Gong Cannon Burning Theory" of the Southern and Northern Dynasties: the nature is dry and poisonous.
In the clinical practice of traditional Chinese medicine, it can be reduced by matching other traditional Chinese medicines, processing and other methods, and the common method of preparation is: salt burning, salt tonic bone fat Dry poison is alleviated.
I am Xiaoling pharmacist, and finally recommend at home: if you take proprietary Chinese medicines containing psoralen, please regularly monitor liver and kidney function.
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