Although myelodysplastic syndrome (MDS) is a malignant blood disease, many MDS patients have only anemia in the early stages, or even a benign bone marrow image, and only show different degrees of bleeding, anemia and fever until the disease progresses to a later stage.
So, what does the bone marrow look like in an MDS condition?
In patients with MDS, 50% to 70% of patients have pancytopenia, which can also be manifested as a series or two series of cytopenias, and the degree of bone marrow hyperplasia is obviously active, and occasionally hyperactive and hypoplastic. There are pathological erythrocytes, pathological granulocytes, and pathological megakaryotic production.
Bone marrow images are characterized by active bone marrow hyperplasia in most cases, and a small number of normal or decreased hyperplasias, accompanied by pathological hematopoiesis. (1) Red: In addition to the protocells, there are megaloplastic changes at all stages, which can be seen in nuclear fragmentation, nuclear malformation, nuclear lobe, unbalanced development of nuclear plasma, and uneven coloring of cytoplasmic basophils. (2) Granulocyte line: there are maturation disorders. (3) Megakaryocyte line: small megakaryocytes can be seen.
About the MDS bone marrow like protocells
Blast cell division is also to identify low-risk and medium-high-risk MDS patients, but also the distinction between MDS and leukemia, in general, where the type I. + II. blast cells greater than or equal to thirty percent of the MDS, and greater than thirty percent can be diagnosed as acute leukemia. This diagnostic criticality has also been changed many times, and there are also twenty percent critical divisions.
To confirm the diagnosis of MDS, in addition to the bone marrow image, the patient also undergoes peripheral blood tests, bone marrow biopsies, karyotyping analysis of chromosomes and other tests. After diagnosis, a delicate treatment plan should be formulated according to the patient's individual condition, combined with voluntary feelings, symptom manifestations, and laboratory results.
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