Regarding the drug "lipid kang", I previously wrote that "the special red yeast extract of "blood lipid kang" how to reduce cholesterol? " article. Recently, some netizens have proposed to talk about it again, so write another one.
Some people on the Internet also say that lipid kang is medicine, it is not good to take medicine, since it is all red yeast, eat some "natural red yeast".
Is that really the case? Let's start with what kind of medicine lipids are.
【Lipid Kang is a kind of proprietary Chinese medicine】
Lipid Kang, from the nature of the drug belongs to the proprietary Chinese medicine. Because it is extracted from a special red yeast, a kind of Chinese medicine.
Red yeast is formed after rice is infected with red yeast and fermented. It is an ingredient and is also counted as a kind of traditional Chinese medicine, which has the effect of activating blood and dissolving stasis, strengthening the spleen and eliminating food.
As an ingredient, red yeast rice is familiar to many people. Roast meat, roast duck, sprinkle red yeast rice noodles when making curd, and the food becomes red and more attractive. But red yeast rice also has a medicinal effect, and the substances extracted from red yeast yeast can lower cholesterol. I think the ancients used red yeast that can lower cholesterol to cook high-cholesterol meat, which is really smart.
In the early 1990s, researchers at Peking University cultivated a red yeast that can stably produce statins, named special red yeast, and extracted the active ingredient from it to make the drug of lipid kang, which is used to reduce cholesterol. Because it is an active ingredient extracted from Chinese medicine red yeast rather than chemical synthesis, it is a proprietary Chinese medicine.
[Lipid Kang is classified as a "statin" drug]
Statins lower LDL cholesterol in the blood and are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease.
As soon as the advent of blood lipids, it was used to lower blood cholesterol. There are statins and natural statin analogues in the components of lipid kang, the mechanism of action of lipid kang is consistent with statin, and the intensity of the action of lipid kang to reduce cholesterol is similar to that of statin. Therefore, after the advent of lipid Kang, after some clinical research, it was classified as statins, but it is not a single component statin synthesized by chemical synthesis.
As early as 2009, in the "Guidelines for the Prevention and Treatment of Dyslipidemia in Adults in China", Lipid Kang was included in the introduction of statins. In the "Chinese Expert Consensus on Lipid Management in Patients with Ultra-High Risk Atherosclerotic Cardiovascular Disease" released in 2020, Helipidemia was listed as a moderate-intensity statin. The lipid-lowering range of 1.2 g (1200 mg) of blood lipid kang per day is equivalent to 10 to 20 mg of atorvastatin per day, 5 to 10 mg of rosuvastatin, 2 to 4 mg of pitvastatin, 20 to 40 mg of simvastatin, 40 mg of pravastatin, lovastatin, 80 mg of fluvastatin.
【What does lipids rely on to lower cholesterol?】 】
Rely on statins? Not complete; also rely on natural statin analogues, and other beneficial ingredients.
Analysis of the active ingredients of lipid kang found that lipid kang contains the ingredient of lovastatin, but very rarely, only 2.5 mg out of 300 mg per capsule. Eat 4 lipids a day, 1200mg of only 10mg of lovastatin, but why can there be 40mg of lovastatin cholesterol-lowering range?
This is because lipids also contain more than 10 natural statin homologues - "monacolin". These natural statin homologs can also act on enzymes that synthesize cholesterol in the liver, and together play a cholesterol-lowering role. And natural statins don't need to be converted by the liver to function.
There are also ergosterols, flavonoids, a variety of amino acids and other substances in the blood lipid Kangli, which can strengthen the role of statin substances, and can also play an anti-inflammatory, antioxidant, immune and other effects. It has even been observed that lipids have the effect of inhibiting tumors.
Therefore, the blood lipid kang content of 10mg lovastatin can be comparable to the cholesterol-lowering level of 40mg lovastatin.
[Compared with statin drugs, there are fewer adverse reactions of lipid kang]
Lipids contain statins and can also have adverse effects of statins, but are safer than other statins. Natural statin analogues of lipid coliolipids can be transformed without liver transformation. Clinical observations have shown that there are fewer adverse reactions to liver damage and myalgia in lipids. Some patients with statin intolerance can also take lipid profiles safely
Lipid Kang has not only been studied in China, but also abroad, and has also been recommended abroad.
[Blood lipid kang comes from red yeast, so is it okay to eat some red yeast to lower blood lipids?] 】
Eating something is fine, not curing the disease.
Because lipids are medicines, drugs have strict standards.
The production of red yeast of blood lipids is specially screened out, and the process of extracting active ingredients has certain requirements, after the process of rough extraction, de-counterfeiting, and requiring the active ingredients inside to reach a certain dose. Lipid Kang is based on lovastatin as the quality control standard, and the content of lovastatin in each 300mg should reach 2.5mg, and it should be kept stable and cannot be mixed with other impurities. This guarantees quality, efficacy and safety.
Natural red yeast rice can be eaten as an ingredient, and there is no harm in general consumption. But it is not so reliable to treat the disease as a drug. Because the active ingredients in these ingredients and health care products in the red yeast are not controlled, nor are they required to be controlled, how much to eat is effective, how effective it is, whether there is damage after eating too much, etc. have not undergone strict clinical research, and it is not clear, so it cannot be used as a medicine.
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Department of Cardiology Hou Xiaoping