Have you often stayed up late and have you ever heard of estazolam as a "good medicine" for insomnia when looking for a way to relieve insomnia?
So, is estazolam right for you, and what are the issues that need to be paid attention to when using it? Let's take a closer look at it to help you sleep healthily.
1. When taking estazolam, these 2 problems are not noticed, and something will happen!
1. Exceeding the recommended dose is equal to "amnesia"
Stezolam belongs to the benzodiazepine class of drugs, and its mechanism of action is mainly related to γ-aminobutyric acid receptors in the central nervous system. γ-aminobutyric acid receptor is a neurotransmitter that acts by inhibiting the excitability of neurons, acting as a sedative and inhibiting central nervous system activity. Estazolam inhibits the excitability of neurotransmission by enhancing the inhibitory effect of γ-aminobutyric acid receptor receptors and promotes the transmission of γ-aminobutyric acid receptors between neurons, resulting in sedative and hypnotic effects.
However, when the dose of estazolam exceeds the recommended range of use by the doctor, the overactivation of the γ-aminobutyric acid receptor receptor by the drug may lead to abnormal depression of the nervous system. This excessive inhibition can affect the normal functioning of the brain, especially when it comes to memory formation and storage.
Specifically, an excess of estazolam may trigger an excessively strong γ-aminobutyric acid receptor Aergic signal between neurons in the brain, resulting in a decrease in neuronal activity levels, which in turn affects the transmission of information between neurons. This disturbance can lead to a loss of short-term memory, the so-called "amnesia" phenomenon, in a short period of time.
2. Long-term use forms dependence
Long-term use of estazolam may lead to the development of tolerance to GABA receptors. The effect of the drug in the brain is by enhancing the inhibitory effect of GABA receptors, but over time, neurons may gradually develop a tolerance to this overactivation, resulting in a gradual diminishing effect of the same dose of the drug in producing the desired effect. In order to maintain the same hypnotic effect, patients may need to increase the dose of medication, which may exacerbate drug dependence.
Long-term use of estazolam may also interfere with the balance of one's own GABA system. Since the drug provides an external GABAergic signal, the body may reduce the degree to which it produces GABA on its own to accommodate the presence of exogenous GABA. This can cause the body to gradually lose its response to naturally occurring sedation signals, making it difficult for people to fall asleep without medication.
Eventually, patients may experience withdrawal symptoms when the drug is discontinued. Withdrawal symptoms include anxiety, insomnia, nervousness, and mood swings, among others, because the body has adapted to the presence of the drug and is unable to quickly adjust back to its normal state when the drug is stopped. So why do we have insomnia?
Second, insomnia generally suggests that there is something wrong with your liver!
Insomnia is a common sleep disorder, and medical views suggest that insomnia may be associated with abnormal liver function.
This is because the liver, as one of the important organs of the human body, plays a key role in maintaining physiological balance and metabolic regulation. Closely related to its function, however, is the body's internal complex circadian clock system, which is a collection of genes and proteins that synchronize with periodic changes in the environment and are responsible for regulating the rhythm of physiological processes. And the liver, as an active participant in this circadian clock system, bears the main responsibility for a part of this.
The circadian clock system is essential for maintaining the body's daily physiological activities and precise time rhythms. There are a large number of circadian clock genes in the liver, which are expressed at different time points and regulate metabolic and biochemical processes in the liver. This rhythm regulation is to adapt to physiological demands at different time periods, such as energy expenditure during the day and repair and synthesis at night.
When liver function is impaired, this circadian clock system can be disrupted. Liver damage may lead to abnormal expression of circadian clock genes, affecting the normal functioning of the entire circadian clock system. This disturbance can disrupt the temporal rhythm in the body, especially when it comes to falling asleep and falling asleep at night. The occurrence of insomnia may be due to the disruption of the biological clock system, resulting in physiological processes that are unable to adapt to the normal sleep cycle, thus affecting the onset of sleep and the quality of sleep.
The liver also plays a key role in glucose metabolism, lipid metabolism, and more. Once there is a problem with the liver, it may lead to fluctuations in blood sugar levels, dyslipidemia and other conditions, and these physiological changes may be closely related to the occurrence of insomnia. For example, erratic blood sugar levels can cause nighttime awakenings, interrupting normal sleep cycles.
The liver also plays a vital role as a detoxification organ in the body, responsible for removing waste and toxins produced in the body and maintaining overall physiological balance. The smooth functioning of this function is essential for the proper functioning of the body. When the liver's function is impaired, this detoxification system can be hindered, causing toxins to build up in the body.
The accumulation of toxins can have a negative impact on the central nervous system, as this is the control center of various physiological processes in the human body. Especially during sleep, the central nervous system plays a key role in regulating the different stages of sleep. If toxin build-up interferes with the normal functioning of the central nervous system, it can lead to sleep disorders, including difficulty falling asleep, sleep disruption, and decreased sleep quality.
Of course, although there is a certain relationship between liver problems and insomnia, insomnia may be affected by many factors, including psychology, environment, lifestyle, etc. Therefore, in the face of insomnia, in addition to paying attention to liver health, it is also necessary to comprehensively evaluate the individual's life Xi habits, mental state and other factors to formulate a comprehensive treatment plan. If you usually suffer from insomnia, these 3 methods can help you fall asleep quickly!
3. Severe insomnia, 3 ways to fall asleep quickly in 5 minutes!
1. Stay in the bath or foot bath for 10-15 minutes before going to sleep
This method is based on the regulation of body temperature and the relaxing effect of hot water on the muscles. Soaking in hot water causes the body temperature to rise, and when you leave the water, the body temperature begins to drop, which mimics the natural process of the body falling asleep. Hot water also soothes muscle tension and helps to relax the body and create better conditions for falling asleep. A soaking time of 10 to 15 minutes is sufficient to obtain these benefits, but the water temperature should be avoided as it may be counterproductive.
2. Yawn over and over again
Yawning is a physiological response related to sleep and wakefulness states, and by simulating yawning, it can send a signal to the brain to be "tired", prompting the body to enter a state of readiness for sleep. Rapid, deep yawning movements may stimulate the visual and nervous systems, allowing the brain to gradually enter a state of relaxation and prepare for sleep. This simple technique can be done in under 5 minutes and is a quick way to alleviate insomnia.
3. Listen to the music of the waves and the forest for 10 minutes
This method is based on the principle of sound therapy, which helps to adjust the active state of the brain and reduce inner anxiety and stress by listening to soothing natural sounds. The music of the waves and the forest is usually characterized by a stable and gentle rhythm, which can induce the body to enter a state of relaxation and provide a beneficial environment for falling asleep quickly. Headphones can be used as an option to better block out outside noise and ensure maximum music impact.
summary
Estezolam plays an active role in the treatment of insomnia, but it must be used with caution. Through scientific medication and a healthy lifestyle, we can better manage insomnia, improve overall sleep quality, and usher in a healthier and more fulfilling life.