#Article First Release Challenge#The incidence of diabetes among adults in mainland China is about 10%, and according to the World Health Organization (WTO), the incidence of diabetes in hypertensive patients is 2-3 times that of the normal population, while 50% of diabetic patients are accompanied by varying degrees of hypertension.
In addition to encephalopathy and coronary heart disease caused by arteriosclerosis, diabetic nephropathy and renal failure are among the most serious complications, and hypertension also aggravates renal damage.
Therefore, it is very important for diabetic patients to control hypertension, and many hospitals in China have reported that in patients with diabetes and hypertension, valsartan and amlodipine can be used in combination, and valsartan amlodipine tablets can also be directly selected, which can better control blood pressure, blood lipids and blood glucose levels than a single antihypertensive drug, thereby reducing the occurrence of cardiovascular and cerebrovascular adverse events (cerebral infarction, myocardial infarction) and diabetic nephropathy in patients.
Valsartan is a potent angiotensin II receptor antagonist (ARB), dilating peripheral blood vessels, lowering blood pressure, improving cardiac function, preventing atherosclerosis, has obvious effects on renal artery dilation, improves renal blood circulation, reduces the risk of diabetic nephropathy, and inhibits insulin resistance (IR) in patients, which is conducive to blood sugar control.
Amlodipine is a calcium channel antagonist (CCB), which reduces vascular smooth muscle tone, reduces myocardial contractility, lowers blood pressure while protecting cardiac function, prevents atherosclerosis, and reduces the risk of cerebral infarction and myocardial infarction.
We should pay attention to the use of the above two antihypertensive drugs, pregnant and lactating women are prohibited, patients with severe liver and kidney insufficiency should be cautious under the guidance of doctors, for low sodium dehydration, long time without eating or drinking, it is easy to lead to hypotensive reaction, and when using diuretics at the same time, we should pay attention to checking electrolytes to prevent electrolyte disorders such as low sodium and high potassium.
Common side effects of the two drugs include gastrointestinal reactions, headache, insomnia, angioedema, and skin allergic rash.
Finally, it is emphasized that the selection and combination of antihypertensive drugs should be consulted with a specialist doctor in advance to ensure the safety of medication.
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