The owner of su mu or xileti may have had such an experience.
When taking them to the hospital for insect repellent or medication, pet doctors often act with extra caution.
Other dogs prescribe medicine for 10 minutes, and when they get here, they may not be able to stop for 20 minutes.
This is mainly because The Collie is sensitive to certain drugs, and doctors have to be careful for the safety of the hairy children.1
But the Collie is not just Su Mu and Hilti.
- What is Curley? Why is it poisoned?
Collie is not a single breed, but a general term for a range of sheepdogs with similar blood ties.
The most common are Scottish Shepherds, Shorthair Shepherds, Hilti Shepherds, Border Collies, australian Shepherds.
They all belong to the "Curly Dog".
They are a relatively healthy dog breed themselves, but some of them may have MDR1 gene defects, making them extremely sensitive to certain antibiotics and steroids.
For example, the most famous ivermectin.
It is a drug that is often used to treat skin diseases in animals and has a good effect on repelling parasites inside and outside animals, especially nematodes and arthropods.
If your dog has ever suffered from severe mite disease, it may have been given this small injection, which can be a little more painful than other injections. (Don't ask me why I know...) ）
It is cheap and works well, so it is an essential medicine for pet hospitals.
However, dogs with MDR1 gene defects, because they cannot synthesize P-glycoprotein, cannot be metabolized for this drug, which will cause the concentration of drugs and metabolites in the brain to rise, resulting in various toxic reactions in the brain and nerves.
This reaction is irreversible, and there is no specific antidote, so once poisoned the dog it will be very dangerous.
Therefore, clinically, for Collie dogs, serraminin is usually used to treat and control similar mite disease.
But in fact, not only collie dogs have MDR1 gene defects, but they are not only toxic to ivermectin.
- Hairy children must pay attention to safety!
According to expert studies of genetics, defects in the MDR1 gene are present in many dog breeds.
It's just that it's more prevalent overall in "Curly", exceeding 50% in some samples and much lower in other breeds.
But it is not nothing, such as the ancient English Shepherd, the German Shepherd, and some mixed breed dogs, it does exist, and some account for a lot of it.
There are now better kennels, and when breeding these dogs, genetic screening will be carried out specifically, and dogs that do not have MDR1 gene defects will be selected as breeding dogs to solve health problems from the source.
However, for more owners, it is more realistic to pay attention to the safety of medication.
In addition to the P-glycoprotein transport system effect of ivermectin, the following drugs also have potential risks.
It is worth noting that the above drugs are not necessarily like ivermectin, which often produce very serious toxic reactions.
Some are potentially dangerous, and some can be used with caution in a safe dose, but be sure to listen to a doctor when using it!
If your furry child is a high-risk dog breed, be sure to be careful about safety.
If it is a Collie, even if the doctor does not ask, it must be told in advance - after all, the owner can not expect every doctor to be a dog breed expert.
If possible, they can also be taken to the relevant institutions for DNA testing.
Through the test results, it is possible to understand the risks of dog genes, and it can be more targeted in the future daily management and drug safety.
It was a cold day, and there was heavy snow outside the office.
I hope that everyone can take care of their bodies in the cold winter.
Be sure to be healthy and healthy, tiger and tiger, and welcome the new year!
The source of the image comes from the network, intrusion and deletion