As we age, various diseases will also appear. Everyone should have heard of diabetes, which manifests itself as fat in appearance. In fact, the current social development is relatively fast, and everyone's living standards are gradually improving. In terms of diet, some people may not pay attention to nutritional collocation, only eat big fish and meat, so that the gastrointestinal pressure is too large, which can easily cause diabetes.
Diabetes mellitus is characterized by hyperglycemia and is a metabolic disease. According to the data, the number of people suffering from diabetes is very large. Moreover, if not treated in time, it may lead to chronic damage to the heart, blood vessels, and nerves. Therefore, we must pay more attention to diabetes. At present, the medical community has developed a new drug to treat diabetes, called dapagliflozin. According to patient feedback, the drug is extremely effective.
First, how much do you know about hypoglycemic drugs
Before the advent of dapagliflozin, we also had a lot of other hypoglycemic drugs. Next, let's take a look at traditional hypoglycemic drugs.
1. Species
Metformin. The drug of choice, which lowers blood sugar primarily by inhibiting gluconeogenesis, is generally used in obese or overweight diabetics.
Sulfonylurea hypoglycemic drugs. These drugs can promote the secretion of insulin in patients and can reduce blood glucose on an empty stomach or after meals.
Insulin sensitizers. The effect of lowering blood sugar is achieved mainly by increasing insulin sensitivity.
Glycosidase inhibitors. This type of drug mainly inhibits the absorption of carbohydrates in the gastrointestinal tract, to achieve the effect of lowering blood sugar 2 hours after a meal, and the effect on fasting blood sugar is not very obvious.
2. Side effects
Drugs have side effects to a greater or lesser extent. Metformin is no exception, it lowers blood sugar at the same time, has a certain stimulation of the stomach and intestines. Patients may have diarrhea or indigestion and are at risk of lactic acidosis.
Sulfonylurea hypoglycemic drugs work well, but the force is too large, and the blood sugar may be too low. It reduces the number of white blood cells in the body, which can lead to a sore throat and a slight hyperthermia. Sulfonylurea hypoglycemic drugs will also have the side effects of hemolytic anemia, resulting in fatigue and weakness and lack of energy. Patients should monitor their own situation in time, if the body has obvious discomfort, they should go to the hospital to ask the doctor, and if necessary, they can change the dressing.
Insulin sensitizers lower blood sugar by increasing the sensitivity of insulin, but can cause the patient to become edematous. Puffiness can lead to weight gain in patients, and if the growth is not very pronounced, the patient can be negligible.
Glycosidase inhibitors have fewer side effects than other drugs, but they experience flatulence, which increases intra-abdominal gas. When taking drugs, patients should ensure that their existing conditions and the side effects of the drugs do not conflict, otherwise it will only be counterproductive.
The above is the interpretation of traditional hypoglycemic drugs, so what are the characteristics of the new dapagliflozin? Is it more advanced in its production and is it more effective? What are its side effects?
Second, the 2 advantages of dapagliflozin
1. Good hypoglycemic effect
It is reported that SGLT-2 dominates the glucose absorption process of the human body, and dapagliflozin can inhibit the absorption process of glucose and reduce the blood sugar content in the human body. Glucose is excreted from the urine, and the purpose of lowering glucose is finally achieved. Moreover, this hypoglycemic mechanism of dapagliflozin does not cause hypoglycemia.
In addition to this, it can also help patients control blood pressure. Hypertension is a chronic disease that can easily trigger cardiovascular disease. Dapagliflozin helps keep blood pressure in the normal range and reduces the outbreak rate of cardiovascular disease. It also has a weight loss effect, obesity is an important factor in causing disease, and it can make girls fall into body anxiety. Dapagliflozin helps patients excrete excess sugar and promotes good health.
2. Protect human organs
Diabetes is prone to complications, and dapagliflozin can avoid complications and play a certain protective role in human organs. First of all, the drug has less damage to bones and a lower probability of fractures.
Secondly, it can protect our cardiovascular system and also has a certain improvement function for heart disease. Nowadays, cardiovascular disease is also very serious, and dapagliflozin can reduce the pre- and post-stress load of the heart, improve and reverse the cardiac remodeling caused by diabetes. Prevent heart failure in patients and reduce mortality from cardiovascular disease.
Finally, it protects our kidneys. The kidneys are important metabolic organs of the human body, and the kidneys are not good enough to cause concomitant diseases. By inhibiting the reabsorption of glucose by the kidneys, dapagliflozin can effectively relieve the burden on the kidneys. It also improves proteinuria, restores glomerular filtration rates, and forms a protective mechanism for the kidneys.
Third, the applicable population of dapagliflozin
1. Type 2 Diabetic
Of all the types of diabetes, type 2 diabetes has the highest number. In clinical data, patients with type 2 diabetes are predominantly hyperglycemia. As the name suggests, this is due to the high blood sugar in the patient's body, the backlog appears, exceeding the normal needs of the human body, resulting in diseases.
Due to high blood sugar, patients with type 2 diabetes will also have dyslipidemia, hypertension and other phenomena. After all, blood sugar, blood pressure, and blood lipids are interrelated and affect each other. Dapagliflozin lowers the patient's blood sugar, so that the blood glucose content in the patient's body remains within the normal range. Thus avoiding abnormalities in blood pressure and blood lipids.
2. Diabetic patients with chronic kidney disease
Dapagliflozin protects the kidneys. Nephropathy manifests as an effective glomerular filtration rate of less than 60%, and if diabetes is not controlled in time, chronic kidney disease will occur. If chronic kidney disease is severe, it may develop into kidney failure or uremia. Dapagliflozin can improve glomerular filtration rate, and current data show that many patients with chronic kidney disease are slowly getting better. Dapagliz has undoubtedly become a gospel for everyone, and has also achieved a major advance in medicine.
3. Patients with heart failure
Dapagliflozin protects our heart and has the effect of preventing heart failure. Heart failure, usually due to diabetes caused by coronary heart disease, ischemia of the heart muscle, resulting in a decrease in cardiac function. Heart failure can be accompanied by chest discomfort, dyspnea and other symptoms, and dapagliflozin can be effectively avoided. It improves heart function by controlling blood sugar. At present, the use of dapagliflozin in heart failure is also recognized by patients and is gradually becoming popular.
Fourth, the precautions of dapagliflozin
1. Pay attention to dosage
First of all, dapagliflozin is an oral hypoglycemic drug, and we must prescribe the right medicine when taking this drug. Make sure our condition is appropriate for the drug. Secondly, dapagliflozin is effective and can be taken once a day. Moreover, it is generally taken in the morning and is not affected by pre- and post-meal meals. If you have a bad stomach, you can choose to take it after a meal.
The amount taken at one time is five mg, up to a maximum of ten mg. However, the specific amount of drink, or follow the doctor's advice. Doctors recommend drinking as much as you want, don't make up your own mind. If you have taken other hypoglycemic drugs before, the effect is acceptable, do not change it easily.
2. Be aware of side effects
Although dapagliflozin is a new drug and more mature in all aspects, there are also certain side effects. Dapagliflozin can have an effect on the genitourinary system. Because, through a certain mechanism of action, the drug makes sugar excreted from the reproductive system, which will increase the excretion of patients and increase the burden on the reproductive system. If you feel that the drug is affecting your normal life, you can choose to stop the drug or change the medicine.
Dapagliflozin may also cause fractures. The absorption of phosphorus reduces bone density to a certain extent. And dapagliflozin just aggravates the absorption of phosphorus, so that the body's bone density increases beyond the normal range. The smaller the density of the bone, the harder it is, and when it is the opposite, it becomes fragile, which can lead to fractures.
V. Knowing Somewhat About Diabetes
The above introduces the relevant knowledge of dapagliflozin. How much do you know about diabetes?
1. How diabetes is caused
There may be many causes of diabetes, and we must guard against them in our daily lives. First of all, an irregular and unhealthy diet can trigger diabetes. Some people overeat and do not pay attention to dietary collocation, may eat too greasy, all big fish and big meat. This is not good for our physical health, it will increase our weight, so that the sugar content in the body is too high, and there will be disorders. Food contains different nutrients, the role of the body is also different, we should still eat regularly.
Secondly, irregular work and rest can also cause diabetes. Nowadays, many people like to stay up late, and they don't sleep at night after twelve, and their sleep time is seriously insufficient. After ten o'clock in the evening, our organs begin to detoxify, and if we do not fall asleep at this time, it will affect the work of the body organs. Moreover, staying up late will increase blood sugar, and blood sugar is closely related to diabetes, and the impact is self-evident.
Finally, pregnancy has the potential to trigger diabetes. During pregnancy, pregnant women generally eat a lot of food to supplement nutrition, but if too much supplementation far exceeds the body's needs, it will also cause diseases. Moreover, during pregnancy, the body will be very fragile and immunity will decline. Therefore, we must pay more attention to pregnant women and take good care of them.
2. How to prevent diabetes
First, eat a sensible diet. We must pay attention to the nutritional composition of food, so that meat and vegetarian collocation, nutritional balance. Eat until eight points at each meal, don't eat junk food. Vegetables and custard are the most nutritious, and the diet should not be too high in oil, but it should not be too light. Note that the amount of salt put in each meal should also be moderate, and the harm of high salt to the human body is extremely great. When we keep our mouths shut, the disease is far away from us.
Second, maintain good living habits. Sleeping is the time to restore physical function, and staying up late is equivalent to chronic suicide. We need to make a break, go to bed at the end of the day, and don't play with the phone addictively. To quit the bad habit of smoking and drinking, it will not only cause diabetes, but also cause harm to the lungs and kidneys.
Again, exercise a lot. Life lies in exercise, and exercise can strengthen the body. We can get up early for morning workouts, or work out after dinner. There are many diseases, all of which are related to sedentary inactivity. Exercise strengthens our resistance and strengthens the body's metabolism.
Finally, keep in a good mood. Smile, ten years less, the impact of emotions on the disease is also very large. We must maintain a positive and optimistic attitude and dare to fight against the disease. We can find our own interests, expand our social circle, communicate more with others, and divert our attention.
summary
Dapagliflozin is a new hypoglycemic drug and a major breakthrough in the history of medicine. For diabetics, it is also a completely new attempt. Medicine is advancing, medicine is advancing, and we need to believe that our diseases will eventually be cured.
We must use dapagliflozin correctly, understand its applicable conditions, and do the right medicine. Also strictly follow the doctor's advice and take it in moderation. In addition to this, we also need to prevent diabetes in other ways. The cure of the disease is not an overnight effort, and we must be prepared to fight a protracted war. Persistence is victory, as long as we persevere, we will surely usher in the dawn.