With trembling hands, paralysis, dizziness, stiffness, and loss of language control, he tried his best to hide his illness, but he had to face the fact that he had entered the kingdom of disease. Eventually, he controlled one of the brain electrodes with a remote control, allowing himself to live in two different states while seeing the true joy and meaning of life...
Helmut Dubier, a former professor of sociology at the University of Giessen, used his tough brushstrokes to describe his real life after Parkinson's death in Hello, Parkinson's.
Today is World Parkinson's Day, more than 200 years after Parkinson's first discovery.
Parkinson's disease is all around us and is the second most common neurodegenerative disease after Alzheimer's disease. The data shows that the incidence of Parkinson's in people over 65 years old in the mainland is 1.7%. World Health Organization experts predict that by 2030, the number of people with Parkinson's disease in the mainland will reach 8 million.
However, the grim thing is that Parkinson's disease has not yet been cured, and the symptoms can only be controlled by drugs or surgery.
On the one hand, there is a typical "thousand faces" situation in the individual state of patients, and the type of symptoms and the degree of disease vary from person to person. In the past, due to the lack of effective disease research progress and quantitative evaluation technology for treatment effects, it was difficult for patients to obtain a truly personalized treatment plan.
On the other hand, the development of Parkinson's disease to the middle and late stages will seriously affect the quality of life of patients, resulting in life can not take care of themselves, to patients, family members, national medical insurance are a major burden. However, the traditional Parkinson's diagnosis is mainly based on patient complaints, expert naked eye observation, etc., and relies heavily on doctors' experience. However, there are only three or four hundred Parkinson's disease experts in the mainland, and there is a large gap. The doctor-patient ratio is 1:3000, which is in a serious imbalance. In the early stages, misdiagnosis, missed diagnosis and other situations often occur.
Since the outbreak of COVID-19, the daily life, medical visits and disease management of people with Parkinson's disease have faced greater challenges. Therefore, the use of innovative technologies to achieve the upgrading of diagnosis and treatment technology for central nervous system diseases, the development of digital health technology tools including artificial intelligence-based digital health technology tools, digital biomarkers and clinical decision support and other products, has become the key to solving standardization problems, improving diagnostic efficiency and accuracy, avoiding misdiagnosis and missed diagnosis, as well as achieving personalized treatment and filling the gap of quality doctors.
How to integrate the diagnosis and treatment of Parkinson's disease?
In the face of Parkinson's long-term treatment pain points, in addition to drug research and development companies, many explorers have also begun to conduct relevant solution research on this disease, and have developed a series of innovative solutions including wearable devices, neurosurgical robots, neurological disease medical devices, eye tracking therapy, and disease management cloud platforms.
A global Parkinson's disease treatment company
Note: Due to time and information, statistics may not be complete
Among the explorers of Parkinson's disease treatment options, we can even see the figure of Verily, who was born from Google. To conquer Parkinson's, Verily partnered with Radboud University in the Netherlands to launch a personalized Parkinson's disease program and Launchverly Study Watch for research and clinical trials to see how Parkinson's patients can manage their daily lives.
An innovative medical technology company in China called Shenzhen Zhenluo Technology Co., Ltd. (hereinafter referred to as "Zhenluo Science") has the same determination to solve the pain points of Parkinson's disease diagnosis and treatment. Founded in 2013, zhenluo science, although the company was only 5 people at the beginning of the establishment, zhenluo science still chose to enter the parkinson's field where the market and research were still blank at that time, and began the "GYENNO Rui Meal + Medical Power" project.
Time has gone by for years. In December 2021, Zhenluo Science signed a cooperation agreement with Huazhong University of Science and Technology to jointly build an intelligent digital medical technology center for neurological diseases, focusing on the research of human movement, behavior and physiological perception technology and its multimodal information fusion method, the research of digital biomarkers of nervous system diseases and their new diagnostic evaluation technology, the research of data-driven digital therapy for nervous system diseases, and the research of new neural regulation technology. Prior to this, As the world's leading new technology company in the field of Parkinson's disease, Zhenluo Sciences established a global collaboration with Bastiaan R. Bloem, an academician of the European Academy of Sciences and a professor of neurology at Radboudumc, to further explore how to use Innovative Chinese medical technologies to achieve global patient and clinical benefits.
Today, Zhenluo Science has independently developed a series of innovative products using innovative artificial intelligence digital technology, and at the same time combined with online and offline closed-loop personalized chronic disease management system to promote the development of Parkinson's disease diagnosis and treatment.
In terms of innovative diagnosis, Zhenluo Science has developed the Parkinson's Disease Quantitative Assessment and Auxiliary Diagnosis System "Rui Ping" for clinical examination and scientific research based on wearable technology, the Parkinson's Disease Quantitative Assessment and Auxiliary Diagnosis Technology "HEIMDALL" based on machine vision technology, and the Parkinson's Disease Multimodal Multiomics Clinical Data Management and Intelligent Analysis System "Ruiyun".
Among them, the "HEIMDALL" system is currently the world's first and only technology system that can realize the complete intelligent scoring of the MDS-UPDRS scale through a single machine vision technology. In addition to covering the in-hospital scene, the technical system can also cover the out-of-hospital scene at the same time, and patients can perform regular scale evaluation without leaving the house by combining the smart phone. The introduction of the system not only effectively fills the gap in this technology internationally, but also solves the problems of cumbersome parkinson's disease treatment process and fragmentation of follow-up.
Parkinson's disease multi-modal multi-omics clinical data management and intelligent analysis system "Ruiyun" can effectively improve the efficiency of top hospitals and solve the problems of county-level hospitals. It is understood that "Ruiyun" has now carried 5 national key research and development plans related to Parkinson's disease, while covering 217 top three hospitals across the country, and is currently the most mainstream and widely used parkinson's disease multimodal multi-omics clinical data platform.
In terms of innovative treatment, Zhenluo Science has developed the world's first gait assist device "Ruixing", which can automatically identify the frozen gait of Parkinson's disease and intervene in real time, the first rehabilitation equipment "Rui Meal" in China that intelligently assists Parkinson's patients to eat and quantify hand symptoms, "Rui Sleep", a professional nighttime exercise symptom and sleep quality evaluation system for Parkinson's disease patients, and "Medical Power" of Parkinson's disease chronic disease management APP platform. At the same time, a complete closed-loop technology system based on years of precipitation explores digital therapy for Parkinson's disease.
On the occasion of the International Parkinson's Day (World Parkinson's Day), Zhenluo Science's self-operated Parkinson's Disease Specialist Internet Hospital "Zhenluo Internet Hospital" issued by the National Health Commission was also officially launched, based on the complete, continuous, high-dimensional, subjective and objective combination of multimodal data brought by the innovative software and hardware technology solutions independently developed by Zhenluo Science, giving the specialized Internet medical treatment a more solid objective decision-making reference basis, getting rid of the traditional Internet model of "pure service and process platform" The embarrassment of providing patients with practical and effective Internet diagnosis and treatment, personalized chronic disease management and drug purchase services is closed-loop.
At the beginning of its establishment, "Zhenluo Internet Hospital" was already a specialized Internet hospital platform covering the most extensive range of top Parkinson's disease experts in the country. It is reported that during the International Parkinson's Day event, more than 40 well-known experts in Parkinson's disease from all over the country gathered on this platform to provide public welfare consultation for patients.
Dr. Ren Kang, founder of Zhenluo Science, told Arterial Network: "We have been deeply engaged in academic and technical aspects in this field for nearly a decade, all with the aim of achieving our ideal future diagnosis and treatment scenario, that is, the patient's offline Parkinson's disease clinical center conducts a comprehensive assessment through artificial intelligence-based wearable and machine vision technology, and experts combine objective data and AI-assisted decision-making information to formulate accurate and comprehensive treatment strategies for patients; and after patients leave the hospital, they improve symptoms through innovative digital device intervention. Improve the quality of life, and the use of wearable technology, machine vision technology, digital biomarker technology and mobile medical platform, the establishment of non-stop symptom continuous monitoring and remote follow-up, to achieve dynamic intervention, personalized treatment strategy adjustment and drug distribution service closed loop, comprehensive patient benefit is the emotional driving force that has always driven us forward. ”
Parkinson's disease for the next five years
Five years ago, when talking about development planning, Dr. Ren Kang said that Zhenluo Science hopes to provide a complete service closed loop for Parkinson's patients from the four dimensions of assistance, intervention, evaluation and rehabilitation.
Today, whether it is facing the star sea of brain science or the gap in new technology research and product research and development of Parkinson's disease, Zhenluo Science has taken Parkinson's disease as the entry point for central nervous system diseases, focusing on the diagnosis, evaluation, treatment, rehabilitation and personalized chronic disease management of Parkinson's disease, based on the above artificial intelligence digital technology, in-depth clinical cooperation and legal and compliant Internet diagnosis and treatment qualifications, building a composite management closed loop of online and offline, in-hospital and outdoor, software and hardware deep integration for Parkinson's disease patients.
Going back to the original question, can the 8 million Parkinson's patients find the best treatment solution in the digital health era?
From the perspective of the exploration of Zhenluo Science, as long as the future-oriented medical treatment takes the patient's benefit as the core, is driven by the scene, takes the academic as the support, and takes the technology as the foundation, it will certainly be able to effectively improve the disease symptoms, optimize the treatment effect, improve the quality of life, and reduce the burden of disease for the patient.
*Cover image source: 123rf
![16 common sense about the body, mind and money[fig]](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACwAAAAAAQABAAACAkQBADs=)