I believe that everyone has seen Xu Zheng's "I Am Not a Medicine God" in the past few years, and the plot in it is very easy to be moved. It mainly revolves around the story of the masses buying expensive medicines and eating without medicine. Reflecting the difficulties of some patients in real life, people instantly burst into tears.
I am still impressed by a scene in the film where an elderly woman is taken to the police station to inquire about the case and ask them to give an account of the manufacturer of their medicine. But they all chose silence, and the old lady took the policeman's hand and cried and begged it not to be traced any further, because of her illness, the family's money was eaten by her.
First, the use of statins
For many groups with high blood lipids, statins are not unfamiliar to them, lovastatin, simvastatin, etc., these are more common lipid-lowering drugs in the clinic, and are also commonly used in the international community to treat diseases such as cholesterol, which shows that its effect is not generally good.
In the past, most of the hypertension and cardiovascular and cerebral diseases were more common in the elderly group, mainly due to the decline of body immunity and organ failure as they grew older. However, with the progress of the times, most people's irregular living habits, staying up late and working overtime, smoking, drinking, etc., have led to the increasing popularity of these diseases. Many middle-aged and even young people face the threat of these diseases, and the demand for statins is growing.
At this point, should we also reflect on ourselves? Originally, it was a disease that only some elderly people have, so why are some young people recruited now? This is mainly because our current life is too "comfortable", many young people play mobile phones until midnight every day, order takeaway when they are hungry, have not been out of the house, and have not gone outside to exercise. All of this has led to a great decline in our body's immunity, and the disease is easy to find.
The essence of statins is a reductase inhibitor, and its role is mainly to be able to effectively reduce cholesterol and low-density protein in the human body. To a certain extent, it can also reduce the content of some other enzymes in the human body. So hetines can be considered to be a good treatment for hypertension and hyperlipidemia.
The reason why such drugs can have such a good effect is because it can forcibly inhibit enzymes related to the synthesis of endogenous cholesterol, thereby blocking the reaction of excessive synthesis of cholesterol in cells, thereby stimulating the feedback of LDL on the surface of the cell membrane and giving it a signal to reduce the number of secretions.
But the effect of buttin does not stop there, in addition to being able to effectively reduce high blood pressure, statins also have a significant effect in the treatment of osteoporosis and anti-tumor. In addition, in foreign research reports, it is pointed out that statins can also effectively prevent alzheimer's symptoms. However, as far as the current situation on the mainland is concerned, statins are still mainly used in people with high blood lipids.
Of course, we all know that "it is a three-point poison of medicine". Taking statins incorrectly can also have adverse effects on the human body, starting with the dangers of muscle diseases and their livers. When we use excessive amounts, it is likely to cause body soreness, rhabdomyolysis and other pathologies, and many people who rely on taking statins in real life may have a deep understanding.
Many imported statins are very expensive, and some even reach the level of a few dollars a piece. For many patients, this will undoubtedly increase their financial burden, in the movie "I am not a medicine god", the male protagonist is to buy generic drugs for patients.
In fact, generic drugs are not counterfeit drugs, but drugs that have the same active ingredients and route of use as the original drugs. In the mainland, in order to reduce the pressure on many patients, a lot of generic drug research has also been manufactured, although the efficacy is not as good as the original version, but the cost is low. This also plays a big role for patients.
At present, more than 80% of drugs in the mainland are generic drugs, but this is also required to go online after safety verification. At the same time as the high price of imported drugs, it has also been found that many domestic statin generic drugs have the same efficacy as imported ones. But why is it so different in terms of price? This makes many people very confused. Why is the price difference between imported and domestic drugs so large?
Second, the price difference is very large
In the hearts of many Chinese people, they may believe in the theory of "one penny for one price", so they believe that the efficacy of high-priced imported drugs is better, while the efficacy of low-cost domestic drugs is relatively poor. This is also the main reason why many patients continue to buy imported drugs even though they know that imported drugs are very expensive.
In fact, the reason why our domestic drugs are cheap, the reason why imported drugs are so expensive, the reason why they are not so simple as we think, many times, imported drugs are more expensive than domestic drugs, a small part of its identity reasons, more importantly, its "reform and replacement" degree is not the same. At this point, we have to understand the classification of drugs on the market.
There are mainly 7 kinds of statins on the mainland market, which can be divided into three generations in order. The first generation mainly refers to the class of drugs such as lovastatin and pravastatin, and the second generation is mainly fluvastatin; the third generation includes drugs such as atorvastatin and pitvastatin. Different levels of drugs also have different levels of treatment.
New versions of drugs are generally produced by improving the original base medicine. It has better therapeutic efficacy and lower side effects, which is also the difference between imported and domestic. Imported medicines are updated more quickly. This also leads to a huge difference in price. Therefore, we cannot compare domestic and imported drugs with direct ideas, which is incorrect.
Because we are not comparing the same generation of products at all, the difference in medical efficacy already determines the difference in price. At this time, it is not possible to simply compare imports with domestic products, because there is no comparison.
Therefore, low-priced domestic drugs are not counterfeit and inferior products. Of course, imported medicines are not fairy medicines. As long as we buy drugs through formal channels, their quality and safety are guaranteed, we can all take them with confidence, and we must follow the doctor's advice or the text on the instructions. However, if the symptoms are serious, it is recommended to buy imported drugs.
For those patients who have been out of the dangerous period, the disease has been controlled, and the body is in a healthy and stable state, it is possible to choose to take low-priced domestic drugs for maintenance. However, this series of behaviors must be carried out under the guidance of a doctor, remember not to change and use the medicine without authorization, so as not to cause a certain impact on your body.
Third, the difference in cost
In addition to the difference in price caused by the difference in the degree of renewal of imported drugs and domestic drugs mentioned earlier, the ownership of drugs themselves is also a very important reason for their different values. Many imported drugs are native drugs, that is, original drugs. We should be able to understand that drug research and development requires a certain amount of financial resources and manpower, which is not an easy task. And we don't have a research program for foreign researchers.
The development of a new drug is as short as one or two years, as long as more than ten years is normal, such a huge workload, we can imagine the financial and manpower required. In this way, only large foreign pharmaceutical companies have such strong financial resources to support. Therefore, imported drugs are so expensive, the price itself is not so high, and the high price of drugs is directly proportional to its cost.
Raising the price of drugs to such an expensive price is not what we think of as "unscrupulous traders", who may only want to earn back the cost. We also don't know the money invested in their research institutes, in the process of drug research and development, it is necessary to carry out large-scale, long-term clinical trials, which is also a large expenditure, and those researchers who develop new drugs, companies will also give them rewards, in order to promote their enthusiasm for research and development, so that pharmaceutical companies can move forward.
Generic drugs do not need to be subjected to so many experiments. After all, the definition of generic drugs itself refers to drugs that do not differ much from prototype drugs in terms of dosage, efficacy, and safety, and this is not a tort. Because the patent term of the company to which the drug patent belongs will expire, after the expiration of the company, and the company does not continue the patent, then the world's major manufacturers can start to produce their generic drugs.
In mainland China, 80% of domestic drugs are generic drugs, and they only began to imitate their drugs after the expiration of the patent time of their original drugs. Because the application for a patent also needs a long period of time to limit, the loss of patent protection, the drug in the research and development process, the money required by the manufacturer will be greatly reduced, which is why our domestic drugs are far cheaper than imported drugs.
In fact, before our country joined the World Trade and Economic Organization, it was always a country that mainly produced generic drugs. But we also know that the replacement of diseases is very fast, and there is no corresponding disease after the emergence of corresponding drugs. So when there were no legal generic drugs in China at the beginning, and when we had a lot of demand from the masses, there would be many real "illegal businesses"
In "I am not a medicine god" in the Indian Glenin generic drug is because it was produced during the original drug patent period, it is a drug that is developed in violation of the law, the original drug company found out that after the police, there will be a police in tracking down the illegal drug, the end of the male protagonist is also a bell in prison, but the film also reflects people's helplessness in front of money. But now, our country has taken this issue seriously, with professional teams and enterprises to negotiate.
Therefore, to sum up, the difference between imported drugs and domestic drugs is mainly in that: 1: the research and development process is different, imported drugs need to invest a lot of money and time; domestic drugs have lower costs and shorter time; 2: The production process is different, and the raw materials and purity between domestic drugs and domestic drugs will be greatly different; 3: The quality and efficacy are different, there are also certain differences in the organization between the two, and the impurities and residues contained in domestic drugs are also more than imported drugs.
epilogue
The history of human beings beginning to fight against disease is also the history of human medical development. In the mainland, the most primitive medical knowledge began with Li Shizhen tasting hundred herbs. In modern times, we are also very confident that the medical level will get better and better in the future, and there may be many difficult diseases that we cannot treat now, but in the future we will certainly be able to solve these problems.
However, the entry of various new drugs into the market and the increasing price of drugs have also made the masses helpless, even if the difference between low-cost drugs and regular drugs is not too big, but people are not willing to buy low-cost drugs. In my opinion, we have developed new drugs to heal people, so its price should not be so high that the masses cannot buy it.
Since it is for the sake of the masses, the price of drugs should be reduced so that people can buy regular medicines to treat the sick. There are already many teams of experts negotiating with major medical companies to bring down the price of drugs. We are also pinning our hopes on the country and these professional teams.