Loohoki is the original research product of amlodipine besylate, amlodipine belongs to the calcium channel blocker class antihypertensive drugs, such drugs directly act on the calcium ion channels on vascular smooth muscle cells, inhibit the excitatory contraction coupling triggered by the flow of calcium ions into the cell, relax the blood vessels and reduce blood pressure, this kind of drug reduces systolic blood pressure amplitude, but also has the effect of improving atherosclerosis, especially suitable for simple systolic hypertension, elderly hypertension, hypertension patients with atherosclerosis, such as hypertension with coronary heart disease, Hypertension with carotid artery stenosis, hypertension with peripheral artery occlusion, etc.
Luo Huoxi is a long-acting calcium channel blocker, the antihypertensive effect is maintained for a long time, you can take it once a day, usually in the morning, take a piece of Luo Huoxi, and the blood pressure control is unfavorable in the afternoon, which may be due to:
1 dose is insufficient. Roshoxi currently includes two specifications, namely 5mg / tablet and 10mg / tablet, if you take a tablet of 5mg specifications of Lohoxi every day, for patients with higher blood pressure levels may have insufficient dose problems, you can increase the dose of administration to 10mg, if you are already taking 10mg / tablet specifications, you should not increase the dose, you can combine with other types of antihypertensive drugs, such as the combined use of primate drugs such as enalapril or titmisartan and other sartan drugs, The combination of Luohuoxi and Prati or sartan drugs is the best combination recommended by the industry, and the mechanism of action of the two types of drugs is complementary, and some of their respective adverse reactions can be counteracted to achieve the purpose of synergistic blood pressure reduction.
2The timing of administration is not appropriate
For the situation that the afternoon blood pressure control is unfavorable, it is possible to postpone the morning to the morning or noon, because the peak of the blood drug concentration is reached about 6-12 hours after oral administration, and the postponement of taking the drug can delay the peak time of the blood drug concentration, so that the peak of the blood drug concentration falls as far as possible within the peak period of the afternoon blood pressure, so as to achieve the purpose of controlling the peak of the afternoon blood pressure.
3 Days of medication is insufficient
Blood pressure control is not up to standard, sometimes it is not the problem of insufficient drug dosage and variety, but hypertension patients have just begun to take antihypertensive drugs, antihypertensive drugs have not yet reached a relatively stable blood concentration in the body, resulting in fluctuations in blood pressure suddenly high and low, especially for long-acting Luo huoxi, although the antihypertensive effect of such drugs is maintained for a long time, but in order to achieve this long-term stable antihypertensive ideal state, the time required is also long, for luo huoxi, its elimination half-life is 30-50 hours In order to achieve a steady-state blood concentration, it usually takes 5 half-lives, that is, at least 7-8 days of continuous administration, so if you take Rohoxi antihypertensive for the first time, you must insist on taking the drug at a fixed time every day to facilitate better early to reach the steady-state blood concentration (the speed of drug clearance is close to the speed of drug absorption, and the drug concentration in the blood is maintained in a basically constant state).
In addition, excluding the factors of drugs, high blood pressure in the afternoon, but also related to abnormal fluctuations in emotions, strenuous exercise and other physiological factors, therefore, maintaining a good psychological state and a healthy lifestyle, is also an important factor in controlling hypertension can not be ignored, in addition, whether the correct measurement of blood pressure, whether the sphygmomanometer is accurate is also critical, in short, antihypertensive therapy is actually a comprehensive intervention means, not only need to consider drug factors, but also into the management of environmental factors, physiological, psychological factors, lifestyle and other links It is not recommended for ordinary patients to adjust their own antihypertensive drugs, and should seek the help of professional doctors, according to their own situation, follow the principle of individualized treatment, and seek the most suitable antihypertensive regimen #Health 2022# #健康科普排位赛 #
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