A 40-year-old patient with advanced lung adenocarcinoma came to my clinic and could see that he was extremely anxious and depressed, worried that his child would die before he grew up. Hopefully I can give him a little hope. Repeatedly asked: Have any patients with advanced lung cancer lived for 10 years? I have lived for 10 years, my children have grown up healthy, and I have no regrets when the time comes.
Although it is not long for patients with advanced lung cancer to survive for more than 10 years, they can be encountered by chance in the clinic, and with the widespread use of targeted therapy and immunotherapy, there are more and more such clinical cases. Today I would like to talk about 3 patients with extremely long survival experiences.
Mr. A surname Jiang, diagnosed with lung adenocarcinoma in 2008, lumbar 1 vertebral metastasis, advanced lung cancer, no chance of surgery, so he began first-line, second-line chemotherapy, but after two years it continued to progress, brain metastasis appeared. At this time, the targeted therapeutic drug gefitinib has been out for several years, but the price is expensive, Mr. Jiang gritted his teeth to do genetic testing, there were actually 19 exon mutations, so he decisively sold an old house, began oral gefitinib, and did brain lesions and lung lesion radiation therapy. In this way, After Spending 90,000 Yuan, Mr. Jiang has been taking gefitinib to donate medicine, and what is surprising is that for more than ten years, Mr. Jiang has been re-examined every two months, and his condition has continued to be stable, without any symptoms, no different from normal people.
Mr. B surname Wan, 47 years old, 2012 unknown hoarseness for two months, has been very resistant to physical examination of him, and finally agreed to the family to do the examination, the results of a check found advanced lung cancer, mediastinal lymph node metastasis, single liver metastasis, no surgical opportunity, and then began lung aspiration biopsy and genetic testing, very fortunately, genetic testing suggests that there is an ALK gene mutation, but at that time for this gene targeted drug was not listed in China, had to do chemotherapy first, the early effect is not bad, liver lesions shrink, But after more than a year, the number of liver lesions increased to three. In 2013, zotinib was listed in China, up to 50,000 per month, and there were free drugs. Mr. Wan desperately began to change kzotinib orally, during which time, radiofrequency ablation of liver metastases and stereotactic radiotherapy of primary lung lesions were also carried out. The patient is currently alive and, although in stable condition, has not been afraid to stop the targeted drug.
Mr. C surnamed Chen, 65 years old, has a history of severe smoking for more than 30 years, in 2012 because of the sputum with blood to the hospital for examination, CT found central lung cancer, although the lesion is not large, but close to the lung gate, belongs to the local advanced lung cancer, tracheoscopy suggests low and medium differentiation of squamous cell carcinoma. The patient had good health, began simultaneous chemoradiotherapy after diagnosis, and then continued chemotherapy for six cycles, and the lesion almost disappeared. At the end of 2016, the patient developed metastasis of supraclavicular lymph nodes, and was subjected to local radiotherapy and systemic chemotherapy again, which was controlled for more than three years. At the beginning of 2020, the patient's lung lesions recurred and the mediastinal lymph nodes were enlarged, and chemotherapy combined with immunotherapy was decisively adopted. At present, the patient is still alive, and the 2-year immune maintenance treatment is almost over.
Advanced lung cancer, living for 10 years is not a rare thing, medicine continues to develop, it can be said that the longer you live, the more opportunities to use modern medical technology and drugs. Although the above three cases are individual cases, in summary, a good ending needs to be favorable at the right time. 1. Positive normative treatment; 2. Sufficient economic foundation; 3. Comprehensive treatment that requires multiple treatment modalities without expecting a single treatment modality; 4. A good attitude and never giving up hope.