Cell: Study of intestinal organoids using endodermal organ maps
Cell[IF:41.582]
(1) Mapping of multiple developing endodermal organ cells in the human respiratory system and gastrointestinal tract was plotted; (2) This mapping was used to identify cell states of different cell lines, identify transcriptional regulators associated with cell differentiation, and demonstrate the interaction between organ-specific epithelial stem cells and mesenchymal; (3) Benchmark studies of intestinal organoids (HIOs) were used to reproduce the molecular dynamics of intestinal epithelial stem cell and mesenchymal cell development; (4) intestinal stem cell nest factor NRG1, It can promote the maturation of HIOs midguelial epithelial stem cells, and the main intestinal regulator CDX2 is necessary for the differentiation of intestinal epithelium and mesenchymal.
Charting human development using a multi-endodermal organ atlas and organoid models
2021-05-20, doi: 10.1016/j.cell.2021.04.028
Cell's recently published research, which combines cell transcription mapping and organoid culture techniques, describes a transcriptome profile of endodermal organs covering multiple human respiratory tract and gastrointestinal development, and according to this atlas, provides information about cell status, transcription factors, interactions between organ-specific epithelial stem cells, and mesenchymal. （@nana）