Introduction: It is a natural law for viruses to integrate and recombine genes or genetic mutations in order to survive in the host, but it is really unheard of for a situation like the new crown virus to be anti-customer------ Dr. Tong
Viruses are a seemingly small but vital part of nature, and in the microscopic world, they are the real kings.
Harmonious coexistence between man and nature should not become an empty phrase, otherwise nature will let human beings, the so-called lords of the earth, taste its power, after all, for the earth, human beings may also be a special virus.
Since last month, the new crown virus seems to be making a comeback in the mainland, at least Dr. Tong found that a large number of er-positive or multi-positive patients have appeared in the hospital.
But at present, the situation is controllable, most people have mild symptoms, nothing more than itchy throat, cough, runny nose, and even few patients with fever.
This situation may be good for ordinary people, but I just read a literature yesterday about Italian researchers about the genetic damage of the new crown virus to the human body, which made me creepy, and combined with the "rumors" a few days ago that the United States has admitted that the new crown virus is their laboratory product, I feel that everything is a little bad.
On March 9 this year, researchers at the AIRC Institute of Molecular Oncology in Italy clearly pointed out the idea that the new coronavirus causes DNA damage in humans, and proved this view through in vitro cell culture.
The paper was published in Nature Cell Biology and is titled: SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence.
The saying that the new crown virus can damage human genes has been said for a long time, after all, there has never been a virus that will bring so many and lasting sequelae to humans after infecting the human body, and we also call it a long new crown.
Whatever the name, it is essentially the result of damage to human health, not to mention that a respiratory infection virus can affect almost all human systems, which is absurd in itself, but it is real.
Human life expectancy and health are fundamentally determined by DNA, and acquired living habits or medical care are realized on this basis, in other words, innate life expectancy can only be relatively continued, but can not be fundamentally extended.
Whether the damage to DNA by the new crown virus can lead to a shortening of the life span of infected people remains to be verified, and many humans who have died because of the new crown have at least proved the impact of genetic damage on the length of life.
Scientists in Italy believe that the proteins ORF6 and NSP13 expressed by the new coronavirus can induce the degradation of the DNA damage response kinase CHK1 of human genes through proteasomes and autophagy, resulting in CHK1 loss.
CHK1 deletion can lead to a decrease in the synthesis of DNA deoxyribonucleoside triphosphate (dNTP), which in turn leads to damage to DNA replication, while the new coronavirus nucleocapsid protein (N protein) can inhibit the recruitment of 53BP1 protein, thereby reducing the DNA damage repair process, this simultaneous process of one plus one subtraction seriously hinders the normal gene replication of the human body, resulting in human cell aging and various serious occurrences are inevitable.
In a word, the new crown virus can inhibit its repair while damaging DNA, so why we are so weak and slow to recover after being infected with the new crown virus, and the entire healing process is far more than the root cause of other ordinary viral infection processes.
In this regard, Dr. Tong is just worried about whether the damage of the new crown virus to the human gene can really be repaired, or if the new crown virus has always existed, whether each infection will aggravate this damage, after all, this fundamental damage is incomparable to any other harm, because it directly shortens the length of human life and not other things.
For human beings, what is more important than the length of life, and another point is that for humans who have been infected, will the offspring they reproduce be born with this damaged genetic sequence, and if so, does it mean that the extension of life brought about by the development of medical technology in the past hundred years will be beaten back to pre-liberation at some point?
In short, according to the theory that DNA damage accumulation is related to cancer and aging, those of us infected by the new crown are likely to already have to bear the cost of shortened lifespan, as for what this cost is or how long it will take, I am afraid that only time can give an answer.
Therefore, here Dr. Tong hopes that everyone can do a good job of protection, even if the symptoms of Eryang are very mild, whether to be paralyzed, it is better not to be infected or not infected, after all, what its harm is, really no one knows.