laitimes

Why do monounsaturated fatty acids live longer? Scientists found a study of molecular mechanisms published May 1 in Nature Cell Biology, using a model

author:Doctor Blueberry

Why do monounsaturated fatty acids live longer? Scientists have found the molecular mechanism

In a study published May 1 in Nature Cell Biology, scientists used the model organism Caenorhabditis elegans to observe the effect of eating mono-unsaturated fatty acids MUFA, which not only upregulates the number of intracellular lipid droplets but also the number of peroxisomes. Importantly, nematodes fed MUFA-rich foods live about 35% longer than worms fed standard nematode feed!

Caenorhabditis elegans, about 1 mm long, usually lives 18 to 20 days. In the wild, they live in the soil and feed on bacteria from decaying plants. In this experiment, researchers compared nematodes grown in petri dishes fed oleic acid with nematodes with structurally similar monoparenchymal trans fatty acids.

Spectroscopic observation of nematode intestinal cells by visualizing hydrocarbon bonds for label-free imaging of lipids (SRS) showed that if nematodes were exposed to oleic acid, the number of lipid droplets in nematode intestinal cells increased and they lived longer. In contrast, exposure to trans-oleic acid did not increase the number of intracellular lipid droplets and had no effect on lifespan (Figures 1, 2).

Interestingly, the accumulation of MUFA by ash-2 RNAi also led to the remodeling of many membrane lipids, with an increase in the proportion of MUFA/polyunsaturated fatty acids (PUFAs) in membrane lipids and a decrease in specific membrane lipids-ether lipids. Membrane lipids with low MUFA/PUFA ratios and high ether lipids are associated with increased lipid oxidation. Consistent with this, the peroxidation index—a measure of the likelihood of lipid oxidation—decreased under conditions of MUFA accumulation (Figure 3). These data suggest that MUFA accumulation reduces lipid oxidation. Lipid oxidation of cell membranes can lead to leakage and incapacitation of cell membranes, which can lead to a range of adverse biological effects, reducing lipid oxidation and increasing the lifespan of animals. Genes that block droplet-forming proteins shorten the animal's lifespan to normal levels.

In addition to the number of lipid droplets, the researchers noted an increase in the number of peroxisomes in the intestinal tissue of worms exposed to oleic acid, which contain enzymes involved in metabolism and oxidation, which naturally decrease with age, increasing MUFA, and increasing intracellular peroxidase (Figure 4).

In short, the intake of MUFA increases the increase of two organelles, intracellular lipid droplets and peroxisomes, which work together to protect the lipid oxidation of cell membranes and increase the lifespan of animals. Now you know the role of unsaturated fatty acids such as olive oil and nuts? Paper: Web link

Why do monounsaturated fatty acids live longer? Scientists found a study of molecular mechanisms published May 1 in Nature Cell Biology, using a model
Why do monounsaturated fatty acids live longer? Scientists found a study of molecular mechanisms published May 1 in Nature Cell Biology, using a model
Why do monounsaturated fatty acids live longer? Scientists found a study of molecular mechanisms published May 1 in Nature Cell Biology, using a model
Why do monounsaturated fatty acids live longer? Scientists found a study of molecular mechanisms published May 1 in Nature Cell Biology, using a model

Read on