What is a gout attack? ✦
Gout is closely related to hyperuricemia, but elevated hematuric acid alone is not enough to attack gout. The solubility of uric acid is relatively low, and the solubility of sodium urate salt and calcium urate salt is lower. Various reasons lead to increased blood uric acid, beyond the concentration of uric acid that can be dissolved in the blood, too high uric acid and urate will precipitate crystals, if you encounter cold, alcohol, improper diet, disease, drugs that affect uric acid metabolism and other factors, but also increase the precipitation and deposition of uric acid and urate crystals. These uric acid or urate crystals are deposited in the joint cavity and periarticular tissues, leukocytes engulf, dissolve these uric acid crystals, and release a series of inflammatory cytokines and lysozymes, these compounds in the dissolution, absorption of uric acid at the same time, triggering a series of chemical reactions that are inflammatory reactions, causing peripheral tissue congestion, cellulose exudation, resulting in local tissue redness, swelling and pain, severe cases can cause general malaise, fever and other symptoms.
Who is susceptible to gout? ✦
Who is susceptible to disease, who is not easy to get sick, is not a factor can be determined, genetic predisposing factors and external environment work together to cause gout. Gout tends to occur in middle-aged and elderly men. Lifestyles such as hyperpurine diet, less exercise, and alcohol consumption are the causes of high incidence; people with obesity, diabetes, hypertension, dyslipidemia, coronary heart disease, kidney disease, and the use of drugs such as diuretics are prone to gout; people living in plateau areas, cold areas, and carnivorous ethnic groups and seasonal changes are also the causes of high incidence of gout.
Why do gout recur? ✦
Gout has the characteristics of recurrence, whether there are repeated episodes of gout there are individual differences, but also the influence of environmental factors. Gout attacks often have triggers, some of which can be self-controlled, such as: high purine diet, alcohol consumption, less exercise, irregular medication, nervousness, fatigue, cold, etc.; there are also some unexpected causes, such as: trauma, surgery, stress, other diseases and the influence of drugs.
1
If you can't change the habit of high purine diet, drinking, less exercise, and irregular medication, gout is prone to recurrence;
2
Patients with obesity, diabetes, hypertension, dyslipidemia, etc., cannot avoid gout attacks until weight loss and correction of metabolic abnormalities;
3
Diseases that cause secondary gout are not effectively controlled, and it is easy to recur gout by continuing to use drugs that cause gout.
Current medical technology can not cure gout, but as long as the cause and cause are well controlled, most gout patients can reduce the recurrence of gout, and even some gout patients only have one gout arthritis attack in their lifetime.
Why is gout "son preference"? ✦
There are significantly more men than women in patients with primary gout, and many studies have confirmed that 95% of patients with primary gout are men, a few are postmenopausal women, and women during childbearing rarely suffer from gout.
This is due to the fact that endogenous uric acid production in men is higher than in women, the intake and drinking of exogenous hyperpurine diet are more than in women, and female hormones and menstruation are not conducive to uric acid storage. Secondary gout depends on the nature and extent of the patient's primary disease, therapeutic drugs, etc., and may occur at any age and sex, so women with secondary gout are significantly more likely than primary gout, but there are still more men than women. In recent years, the incidence of gout and hyperuricemia has increased, the proportion of women with hyperuricemia has increased significantly, women have not been blocked from gout, and women also need to prevent gout.
Do young people suffer from gout? ✦
Young people suffering from gout is not uncommon, but also in recent years the largest increase in the incidence of gout population, young people like to pursue a fast-paced modern lifestyle, but also tend to high purine diet, less exercise, drinking, irregular living, etc., obesity has increased significantly.
Gout or hyperuricemia incidence shows a trend of rejuvenation, in recent years, gout-related diseases, such as: diabetes, hypertension, dyslipidemia, etc. are also more and more in the young population, and these diseases increase the concentration of blood uric acid through different ways, if you can not correct various metabolic disorders in time, long-term metabolic abnormalities mutually contribute to each other, inducing cardiovascular and cerebrovascular diseases, arteriosclerosis, kidney damage, nervous system damage, etc.
New Year of the Tiger, Great Luck!
Content Source:
People's Medical Publishing House published "Seeking Medical Advice and Finding Experts - Q&A on Gout Knowledge"
Editor-in-chief: Guo Lixin, Hu Xin