The main drug of metoprolol succinate and metoprolol tartrate are: metoprolol.
There are many friends who have questions, can they change the medicine, how big is the difference between them?
Today Zixian will talk to you about the difference!
One different dosage form
Metoprolol tartrate: is an ordinary tablet. Absorb, distribute, metabolize, and excrete in the body according to the normal metabolic pathways of the drug. Can be broken open and even ground for use.
Metoprolol tartrate: Is a extended-release tablet. It is usually composed of 800-900 microcapsules, each of which can be used as a separate unit. Therefore, it can also be broken open (there are crack marks on the drug), but it cannot be ground.
The duration of action is different
Metoprolol tartrate: is a short-acting drug. Half-life is about 4h, so it needs to be taken multiple times a day (usually twice a day)
Metoprolol succinate: is a long-acting drug. The half-life is about 20h, so take it once a day.
3. Duration of taking the drug
Metoprolol tartrate: is a fat-soluble drug, so if taken with food, it will lead to increased bioavailability. This does not increase the level of efficacy, but rather greatly increases the appearance of side effects: bradycardia, decreased heart rate. Therefore, taking it on an empty stomach is a good choice.
Metoprolol succinate: not affected by food, so it can be done after an empty stomach meal, Zixian suggests: If you have a friend who has a stomach ulcer and other diseases, it is better to eat after meals.
In the clinic, the choice of these two drugs is usually started with a small dose of metoprolol tartrate, and if the dose continues to increase, metoprolol tartrate can be switched to reduce the number of medications and increase patient adherence.
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